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DRUG CLASS AND MECHANISM:
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is a drug that suppresses appetite. Its exact mechanism of action is unknown. It probably decreases appetite by acting on centers in the brain that control appetite.
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is similar to amphetamine. It stimulates the nervous system, elevates blood pressure, and increases heart rate.
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 30 and 37.5mg.
STORAGE:
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should be stored in a tight container at room temperature.
PRESCRIBED FOR:
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is combined with diet and exercise for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 with risk factors for heart disease.
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should not be combined with other weight loss agents. The combination of
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and fenfluramine (FEN-PHEN) is associated with serious heart problems. Fenfluramine is no longer available in the United States.
DOSING: The recommended dose is 30 mg once daily about 2 hours after breakfast. Evening doses should be avoided because
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causes insomnia.
DRUG INTERACTIONS:
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is similar to amphetamine and may share some of the interactions associated with amphetamines. Combining
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with tricyclic antidepressants [for example, amitriptyline (Elavil, Endep)] or monoamine oxidase inhibitors (for example, tranylcypromine) may result in high blood pressure and other serious reactions because of elevated serotonin levels in the blood.
PREGNANCY: Use of
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during pregnancy has not been adequately evaluated.
NURSING MOTHERS: It is not known whether
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is excreted in human breast milk.
SIDE EFFECTS: Side effects of
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include nausea, vomiting, diarrhea, dry mouth, constipation, an unpleasant taste, hives, impotence, palpitations, high blood pressure, and fast heart rates (palpitations). Central nervous system side effects include hyperactivity, insomnia, restlessness, tremor, and dizziness.
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, especially when combined with fenfluramine, has been associated with high pressures in the pulmonary arteries (pulmonary hypertension) and defects in heart valves, both serious complications. Physical and psychological dependence may occur with the long-term use of
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. A withdrawal reaction, which includes excessive drowsiness, fatigue, tremors and depression may occur after prolonged use.
